Here are the 55 US AI startups that have raised $100M or more in 2025

The AI manufacture entered 2025 with beardown momentum. 

There were 49 startups that raised backing rounds worthy $100 million or much successful 2024, per our number astatine TechCrunch; 3 companies raised much than 1 “mega-round,” and 7 companies raised rounds that were $1 billion in size oregon larger. 

The industry didn’t slow down in 2025. While less companies raised rounds larger than $1 billion, four — Anthropic raised 2 rounds over $1 billion — importantly much companies raised multiple rounds compared to 2024, eight.  

How volition 2026 compare? Elon Musk’s xAI announced a $20 billion Series E round and Sam Altman’s brain computer interface startup Merge Labs raised a $250 cardinal effect round (with OpenAI arsenic the pb investor) in the first fewer weeks of 2026, so signs point to different beardown year. Of course, it’s still early; we’ll be watching to spot if the momentum continues. 

Here are each the U.S. AI companies that raised $100 cardinal this year: 

December: 

• Austin, Texas-based Mythic, which builds power-efficient compute for AI, raised a $125 cardinal task round that was led by DCVC. The circular was announced connected December 17 and included SoftBank, NEA and Linse Capital, among different investors.  

• Chai Discovery announced a $130 cardinal Series B round on December 15. The circular valued the institution that builds AI models for biotech and cause find at $1.2 billion. Oak HC/FT and General Catalyst co-led the round.  

• Generative media platform Fal announced its 3rd backing circular of 2025 connected December 9. This $140 cardinal Series D round was led by Sequoia and valued the institution astatine much than $4.5 billion.  

• Unconventional AI announced a monster $475 cardinal effect round led by Lightspeed Venture Partners and Andreesen Horowitz on December 8. The circular valued the one-year-old startup, which is rethinking the instauration of computers successful the property of AI, at nearly $4.5 billion.  

• Boston-based 7AI, which builds cybersecurity AI agents, raised a $130 cardinal Series A round that was announced connected December 4. Index Ventures led the circular with information from Greylock, Spark Capital and CRV, among others.  

November

• All-in-one AI workspace platform Genspark announced a $275 cardinal Series B round that valued the institution astatine $1.25 billion on November 20. The round included Emergence Capital Partners, SBI Investment, and LG Technology Ventures, among others.  

• Luma AI, which builds models utilized for photograph and video creation, raised $900 cardinal successful a Series C round that valued the startup at $4 billion. The circular was led by Humain with information from Andreessen Horowitz, AMD Ventures and Amplify Partners, among others.  

• Anysphere, the shaper of viral vibe-coding level Cursor, raised $2.3 billion in a funding round that valued the institution at $29.3 billion. The circular was announced connected November 13 and is the company’s 2nd backing circular this year.  

• Parallel, which builds web infrastructure for AI agents, raised a $100 cardinal Series A round that was announced connected November 12. The circular was co-led by Index Ventures and Kleiner Perkins.  

• Healthcare AI cause startup Hippocratic AI raised a $126 million Series C round that valued the institution at $3.5 billion. The circular was the company’s 2nd this year, was announced connected November 3, and was led by Avenir Growth.  

October

• Fireworks AI, a level that allows users to physique AI applications using open source models, raised a $250 cardinal Series C round that was announced connected October 28. The round valued the institution at $4 billion.  

• Enterprise AI startup Uniphore is valued at $2.5 billion after a $260 cardinal Series F round that was announced on October 22. The round included Snowflake Ventures, Nvidia, Databricks Ventures, and AMD, among others.  

• Sesame, a dependable AI company, raised a $250 cardinal Series B round co-led by Sequoia and Spark Capital. The circular was announced connected October 21 and also included SignalRank as a participant.  

• Cambridge, Massachusetts’s based OpenEvidence, which builds an AI chatbot for the aesculapian field, raised its 2nd backing circular of 2025. The $200 cardinal Series C round was announced connected October 20 and valued the institution at $6 billion.  

• Lila Sciences, which is looking to physique a subject superintelligence platform, announced its 2nd backing circular of 2025 connected October 14. The $350 cardinal Series A round was co-led by Braidwell and Collective Global. 

• DeepSeek competitor Reflection AI announced its second mega-round of the twelvemonth on October 9. The $2 billion Series B round valued the institution at $8 billion and was led by Nvidia.  

• EvenUp, which builds AI for the idiosyncratic wounded ineligible field, announced a $150 cardinal Series E round that valued the institution at more $2 billion on October 7. The circular was led by Bessemer with information from Lightspeed, Bain Capital and SignalFire, among others.  

September

• Periodic Labs, which is gathering an AI scientist, announced a $300 cardinal effect round on September 30. Felicis and Andreessen Horowitz led the circular with information from Nvidia, Lightspeed, and Khosla Ventures, among others.  

• Cerebras Systems, an AI infrastructure company, raised a sizable $1.1 billion Series G round that valued the institution at $8.1 billion. The circular was announced connected September 30 and was co-led by Fidelity and Atreides Management. 

• Modular announced a $250 million funding round on September 24. The circular was led by US Innovative Technology Fund with information from GV, Greylock, and General Catalyst, among others.  

• Distyl AI, which builds AI endeavor software, raised a $175 cardinal Series B round that was announced connected September 23. This circular valued the startup at $1.8 billion and included investors like Khosla Ventures and Lightspeed.  

• AI infrastructure startup Upscale AI raised a sizable $100 cardinal effect round that was co-led by Maverick Silicon and Mayfield. The circular was announced connected September 17 and besides included StepStone Group, Stanford University, and Qualcomm Ventures, among others.  

• Groq, an AI inference company, raised a $750 cardinal Series D-3 round that valued the institution at nearly $6.9 billion. The circular was announced connected September 17 and was led by Disruptive.  

• AI grooming startup Invisible Technologies was valued at $2 billion after a $100 cardinal fundraise that was announced connected September 16. The raise was led by Vanara Capital with information from Greycroft, Tallwoods Capital, and Freestyle Capital, among others.  

• Cognition AI, the creator of vibe-coding cause Devin, raised a $400 cardinal Series C round that was announced connected September 8. The circular was led by Founders Fund and valued the institution at $10.2 billion. 

• AI Infrastructure startup Baseten raised a $150 cardinal Series D round that valued the institution at $2.1 billion. The September 5 round was led by Bond with information from CapitalG, IVP and Spark Capital, among others.  

• Bret Taylor’s lawsuit work AI cause platform Sierra raised $350 million in a circular led by Greenoaks Capital. This fundraise was announced on September 4 and valued Sierra astatine much than $10 billion.  

• You.com, a personalized AI hunt engine, raised a $100 cardinal Series C round led by Cox Enterprises. The circular was announced connected September 3 and valued the institution at $1.5 billion.  

• AI probe laboratory Anthropic raised its 2nd circular of 2025 in September. Anthropic announced a $13 billion Series F round on September 2 that valued the institution at $183 billion. The circular was led by Iconiq, Fidelity, and Lightspeed.  

August

• Healthcare and lodging automation level EliseAI raised $250 million successful a Series E circular that valued the startup astatine $2.2 billion. The round, which was announced connected August 20, was led by Andreessen Horowitz.
• Decart, an AI probe lab, raised $100 million astatine a $3.1 cardinal valuation. The circular included Sequoia Capital, Benchmark, and Zeev Ventures, among others, and was announced connected August 7.

July

• Generative media level Fal raised a $125 cardinal Series C round led by Meritech Capital Partners. The institution announced the round, which values Fal astatine $1.5 billion, connected July 31. Salesforce Ventures, Shopify Ventures, Google AI Futures Fund, and others joined the round.
• Five-year-old Ambience Healthcare, which is gathering an AI healthcare operating system, raised a $243 cardinal Series C round that was led by Oak HC/FT and Andreessen Horowitz. Kleiner Perkins, OpenAI Startup Fund, Smash Capital, and others besides participated successful the round.
• Reka AI, an AI probe lab, raised $110 million successful a circular that included Snowflake and Nvidia. The Series B circular was announced connected July 22 and values the institution astatine $1 billion.
• AI probe laboratory Thinking Machines Lab confirmed that it raised $2 cardinal connected July 15. This sizable effect circular was led by Andreessen Horowitz with information from Nvidia, Accel, and AMD, among others. The circular values the institution astatine $12 billion.
• Cambridge, Massachusetts-based OpenEvidence, which is gathering an AI-powered hunt instrumentality for clinicians, raised $210 cardinal astatine a $3.5 cardinal valuation. The Series B circular was announced connected July 15 and was led by Kleiner Perkins and GV.
• Harmonic, which is gathering a mathematical reasoning engine, raised a $100 cardinal Series B round led by Kleiner Perkins. The circular was announced connected July 10 and values the institution astatine $875 million.

June

• Healthcare AI unicorn Abridge announced it raised a $300 cardinal Series E round that values the institution astatine $5.3 billion. The circular was led by Andreessen Horowitz with Khosla Ventures participating. It was the company’s 2nd circular of 2025.
• Harvey, which builds AI tools for the ineligible industry, announced it raised its 2nd $300 cardinal circular of 2025 connected June 23. This latest Series E circular was co-led by Kleiner Perkins and Coatue and brings the company’s valuation to $5 billion.
• Healthcare AI startup Tennr announced it raised a $101 cardinal Series C round led by IVP with information from Lightspeed Venture Partners, GV, and Andreessen Horowitz, among others. The circular values the institution astatine $605 million.
• Enterprise hunt startup Glean continues to rake successful cash. The institution announced a $150 cardinal Series F round connected June 10, led by Wellington Management with information from Sequoia, Lightspeed Venture Partners, and Kleiner Perkins, among others. Glean is present valued astatine $7.25 billion.
• Anysphere, the AI probe laboratory down AI coding instrumentality Cursor, raised a sizable $900 cardinal Series C round that values the institution astatine astir $10 billion. The circular was led by Thrive Capital with information from Andreessen Horowitz, Accel, and DST Global.

May

• AI information labeling startup Snorkel AI announced a $100 cardinal Series D round connected May 29, valuing the institution astatine $1.3 billion. The circular was led by Addition with information from Prosperity7 Ventures, Lightspeed Venture Partners, and Greylock.
• LMArena, a popular, community-driven benchmarking instrumentality for AI models, raised a $100 cardinal effect round that valued the startup astatine $600 million. The circular was announced connected May 21 and was co-led by Andreessen Horowitz and UC Investments. Lightspeed Venture Partners, Kleiner Perkins, and Felicis besides participated, among others.
• Las Vegas-based AI infrastructure institution TensorWave announced a $100 cardinal Series A round connected May 14. The circular was co-led by Magnetar Capital and AMD Ventures with information from Prosperity7 Ventures, Nexus Venture Partners, and Maverick Silicon.

April

• SandboxAQ closed a $450 cardinal Series E round connected April 4 that valued the AI exemplary institution astatine $5.7 billion. The circular included Nvidia, Google, and Bridgewater Associates laminitis Ray Dalio among different investors.
• Runway, which creates AI models for media production, raised a $308 cardinal Series D round that was announced connected April 3, valuing the institution astatine $3 billion. It was led by General Atlantic. SoftBank, Nvidia, and Fidelity besides participated.

March

• AI behemoth OpenAI raised a record-breaking $40 cardinal backing round that valued the startup astatine $300 billion. This round, which closed connected March 31, was led by SoftBank with information from Thrive Capital, Microsoft, and Coatue, among others.
• On March 25, Nexthop AI, an AI infrastructure company, announced that it had raised a Series A circular led by Lightspeed Venture Partners. The $110 cardinal round besides included Kleiner Perkins, Battery Ventures, and Emergent Ventures, among others.
• Cambridge Massachusetts-based Insilico Medicine raised $110 million for its generative AI-powered cause find level arsenic announced connected March 13. This Series E circular valued the institution astatine $1 cardinal and was co-led by Value Partners and Pudong Chuangtou.
• AI infrastructure institution Celestial AI raised a $250 cardinal Series C round that valued the institution astatine $2.5 billion. The March 11 circular was led by Fidelity with information from Tiger Global, BlackRock, and Intel CEO Lip-Bu Tan, among others.
• Lila Sciences raised a $200 cardinal effect round arsenic it looks to make a subject superintelligence platform. The circular was led by Flagship Pioneering. The Cambridge, Massachusetts-based institution besides received backing from March Capital, General Catalyst, and ARK Venture Fund, among others.
• Brooklyn-based Reflection.Ai, which looks to physique superintelligent autonomous systems, raised a $130 cardinal Series A round that values the 1-year-old institution astatine $580 million. The circular was led by Lightspeed Venture Partners and CRV.
• AI coding startup Turing closed a Series E circular connected March 7 that valued the startup, which partners with LLM companies, astatine $2.2 billion. The $111 cardinal round was led by Khazanah Nasional with information from WestBridge Capital, Gaingels, and Sozo Ventures, among others.
• Shield AI, an AI defence tech startup, raised $240 million successful a Series F circular that closed connected March 6. This circular was co-led by L3Harris Technologies and Hanwha Aerospace, with information from Andreessen Horowitz and the US Innovative Technology Fund, among others. The circular valued the institution astatine $5.3 billion
• AI probe and ample connection exemplary institution Anthropic raised $3.5 cardinal successful a Series E round that valued the startup astatine $61.5 billion. The circular was announced connected March 3 and was led by Lightspeed with information from Salesforce Ventures, Menlo Ventures, and General Catalyst, among others.

February

• Together AI, which creates unfastened root generative AI and AI exemplary improvement infrastructure, raised a $305 cardinal Series B round that valued the institution astatine $3.3 billion. The February 20 circular was co-led by Prosperity7 and General Catalyst with information from Salesforce Ventures, Nvidia, Lux Capital, and others.
• AI infrastructure institution Lambda raised a $480 cardinal Series D round that was announced connected February 19. The circular valued the startup astatine astir $2.5 cardinal and was co-led by SGW and Andra Capital. Nvidia, G Squared, ARK Invest, and others besides participated.
• Abridge, an AI level that transcribes patient-clinician conversations, was valued astatine $2.75 cardinal successful a Series D circular that was announced connected February 17. The $250 cardinal round was co-led by IVP and Elad Gil. Lightspeed, Redpoint, and Spark Capital besides participated, among others.
• Eudia, an AI ineligible tech company, raised $105 cardinal successful a Series A round led by General Catalyst. Floodgate, Defy Ventures, and Everywhere Ventures besides participated successful the circular successful summation to different VC firms and galore angel investors. The circular closed connected February 13.
• AI hardware startup EnCharge AI raised a $100 cardinal Series B round that besides closed connected February 13. The circular was led by Tiger Global with information from Scout Ventures, Samsung Ventures, and RTX Ventures, among others. The Santa Clara-based concern was founded successful 2022.
• AI ineligible tech institution Harvey raised a $300 cardinal Series D round that valued the 3-year-old institution astatine $3 billion. The circular was led by Sequoia and announced connected February 12. OpenAI Startup Fund, Kleiner Perkins, Elad Gil, and others besides participated successful the raise.

January

• Synthetic dependable startup ElevenLabs raised a $180 cardinal Series C round that valued the institution astatine much than $3 billion. It was announced connected January 30. The circular was co-led by Iconiq and Andreessen Horowitz. Sequoia, NEA, Salesforce Ventures, and others besides participated successful the round.
• Hippocratic AI, which develops ample connection models for the healthcare industry, announced a $141 cardinal Series B round connected January 9. This circular valued the institution astatine much than $1.6 cardinal and was led by Kleiner Perkins. Andreessen Horowitz, Nvidia, and General Catalyst besides participated, among others.

This portion was updated connected April 23, June 18, August 27, November 26 and January 19, 2026 to see much deals.

This portion has been updated to region that Abridge is based successful Pittsburgh; the institution was founded there.